John L. Ubels, 1976-2018 | Heritage Hall, Hekman Library

By Laurie Haan

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Collection Overview

Title: John L. Ubels, 1976-2018

ID: COLL/593

Primary Creator: Ubels, John L (June 9, 1952-)

Extent: 50.0 Cubic Feet

Date Acquired: 05/17/2018

Subjects: Ophthalmology, Physiology, Scientific Research

Languages: English

Abstract

The John L. Ubels Papers contain papers from Ubels’s career as a professor and scientific consultant. This collection consists of 1.5 linear feet of reports and published studies written between 1976 and 2008. Many of the reports were written for Alcon Laboratories, Ltd.

Scope and Contents of the Materials

Collection Historical Note

John L. Ubels was born in Modesto, California on June 9, 1952. He earned a Bachelor of Science degree from Calvin College, a Master of Science degree from the University of Michigan, and a PhD in animal physiology from Michigan State University. He later taught biology at Calvin College from 1995 to 2016.

Dr. Ubels taught human physiology and cell physiology during his time at Calvin University. He led an interim sailing course in Florida and an eye care service-learning interim course in Tijuana, Mexico. During his years at Calvin, he mentored 56 students in his research lab. He did extensive research for Alcon Research, Ltd. on ophthalmology, particularly dry eyes treatments. He did extensive testing for the development of Systane and Artificial Tears. Over the past 44 years, he has published 104 papers and chapters on every part of the eye of fish, amphibians and mammals, including humans. During his retirement, he teaches part time at the Michigan State University College of Human Medicine and is a guest scientist at the Van Andel Research Institute.

Biographical Note

Dr. Ubels taught human physiology and cell physiology during his time at Calvin University. He led an interim sailing course in Florida and an eye care service learning interim course in Tijuana, Mexico. During his years at Calvin, he mentored 56 students in his research lab. He did extensive research for Alcon Research Ltd. on opthmology, particularly dry eyes treatments. He did extensive testing for the development of Systane and Artifical Tears. Over the past 44 years, he has published 104 papers and chapters on every part of the eye of fish, amphibians and mammals, including humans. During his retirement, he teaches part time at the Michigan State University College of Human Medicine and is a guest scientist at the Van Andel Research Institute

Subject/Index Terms

Ophthalmology
Physiology
Scientific Research

Administrative Information

Repository: Heritage Hall, Hekman Library

Access Restrictions: <span style="color: rgb(16, 55, 93); font-family: Verdana, Arial, sans-serif; font-size: 12.96px;">Collection held in Heritage Hall; materials are not available for circulation</span>

Acquisition Source: Gift of John L. Ubels

Acquisition Method: Donation

Box and Folder Listing

Browse by Series:

[Series 1: General Files],
[Series 2: Published Articles],
[Series 3: Reports to Alcon Research, Ltd.],
[All]

Series 1: General Files

Box 1

Folder 1: Research Fellowship Application, "Penetration and Metabolism of Retinoids in the Cornea" --- 1979
Folder 2: "Ocular Oxygen Toxicity: The Effect of Hyperbaric Oxygen on Retinal Na-K ATPase" --- 1980: Manuscript published in Experimental Eye Research
Folder 3: Grant Application: "Uptake and Metabolism of Retinoids by Cornea and Lens" --- 1981
Folder 4: Grant Application: "The Tear Film and the Ocular Surface: Vitamin A in Tears" --- 1984
Folder 5: "Re-epitheliazation of Experimental Cornea Wounds Treated with Topically Applied Retinoids" --- 1982: Paper Published in American Journal of Opthamology
Folder 6: "Retinoid Permeability and Uptake of Corneas of Normal and Vitamin A Deficient Rabbits" --- 1981: Manuscript Published in Archives of Opthamology
Folder 7: Reports on the Development of Bion Tears (Highly Successful Artifical Tear for Treating Dry Eye) Alcon Lab --- 1999-2011
Folder 8: ARVO (Association for Research in Vision and Opthamology) Abstracts --- 2001
Folder 9: "Effects of Aminomethylpropanol on Cells in Culture and the Rabbit Corneal Epithelium" --- 2003
Folder 10: Systane - Summary of Safety Evaluations --- 2005
Folder 11: Final Report: "Effect of 0.1% Benzyl Alcohol on Corneal Epithelial Wound Healing" --- 1987
Folder 12: Progress Report: 'Evaluation of Concepts for Relief of Dry Eye Symptoms" --- 2000
Folder 13: Progress Report: "Carboxyfluorescein Uptake and the Effectiveness of Artificial Tears"
Folder 14: Protocols for Contact Lens Cytotoxicity Project
Folder 15: Report: "Testing of Artificial Tear Formulations" --- 2001

Series 2: Published Articles

Box 2

Folder 1: "Ocular Oxygen Toxicity: The Effect of Hyperbaric Oxygen on the In Vitro Electroretinogram" --- 1976 September 7
Folder 2: "Electrophysiological and Metabolic Responses of the Isolated Teleost Retina To Changes in PO2 and Temperature" --- 1978 March 29
Folder 3: "Retinomotor Activity and the C-wave of the Hypoxic Trout Retina" --- 1979 July
Folder 4: "Ocular Oxygen Toxicity: The Effect of Hyperbaric Oxygen on Retinal Na+ - K+ ATPase --- 1980 February 27
Folder 5: "Retinoid Permeability and Uptake of Corneas of Normal and Vitamin A Deficient Rabbits" --- 1982 November: Reprinted from the Archives of Opthamology
Folder 6: "Measurement of Corneal Epithelial Healing Rates and Corneal Thickness for Evaluation of Ocular Toxicity of Chemical Substances" --- 1982
Folder 7: "A Comparison of Healing of Corneal Epithelial Wounds Stained with Fluorescein or Richardson's Stain" --- 1982 July
Folder 8: "Healing of Experimental Corneal Wounds Treated with Topically Applied Retinoids" --- 1983 March
Folder 9: "Healing of Corneal Epithelial Wounds in Marine and Freshwater Fish" --- 1983
Folder 10: "Vitamin A is Present as a Retinol in the Tears of Humans and Rabbits" --- 1984
Folder 11: "Chorodial Rete Mirabile Function and Resistance to Retinal Oxygen Toxicity in Fish" --- 1984
Folder 12: "Ocular Toxicity of Diethyltoluamide (DEET)" --- 1984
Folder 13: "Corneal Epithelial Wound Healing in Normal and Diabetic Rabbits Treated with Tretinoin" --- 1985 January
Folder 14: "The Efficacy of Retinoic Acid Ointment for Treatment of Xerophtalmia and Corneal Epithelial Wounds" --- 1985
Folder 15: "In Vivo Metabolism of Topically Applied Retional and All-Trans Retinoic Acid by the Rabbit Cornea" --- 1985
Folder 16: "Retinol Secretion by the Lacrimal Gland" --- 1986
Folder 17: "Corneal Endothelial Healing Rate and the Effect of Topical Retinoic Acid" --- 1986
Folder 18: "Treatment of Corneal Xerophthalmia in Rabbits with Micromolar Doses of Topical Retinoic Acid" --- 1987
Folder 19: Report to Alcon Labs: "Drug Uptake and Washout" - IOGEL Lens --- 1987 November 25
Folder 20: Isotretinoin in Lacrimal Gland Fluid and Tears --- 1987
Folder 21: "Effects of Corneal Epithelial Abrasion on Corneal Transparency Aqueous Humor Composition and Lens of Fish" --- 1987
Folder 22: "Role of the Rabbit Nictitating Membrane in Ocular Irritancy Testing" --- 1987
Folder 23: "Vitamin A is Stored as Fatty Acyl Esters of Retinol in the Lacrimal Gland" --- 1988
Folder 24: "Corneal Endothelial Morphology in the Rat" --- 1988
Folder 25: "Tear Secretion and Lacrimal Gland Function of Rabbits Treated wiht Isotretinoin" --- 1988
Folder 26: "Drug Uptake and Release by Hydrogel Intraocular Lens and the Human Cyrstalline Lens" --- 1989
Folder 27: "Esterification of Retinol in Lacrimal Glad" --- 1989
Folder 28: "Electrolyte Composition of Lacrimal Gland F;uid and Tears of Normal and Vitamin A-Deficient Rabbits" --- 1989
Folder 29: "The Relationship Between Secretion of Retinol and Protein by the Lacrimal Gland" --- 1989
Folder 30: Report ot CIBA Vision Copropration, Atlanta, Georgia: "Effect of an Opthalmic Preservative on Corneal Epithelial Wound Healing" --- 1989
Folder 31: Report to S. C. Johnson"Evaluation of Ocular Irritancy of Hair Care Products" --- 1990
Folder 32: "Evaluation of Ocular Irritancy of Hair Care Products" --- 1990
Folder 33: "13-Cis Retinoyl-ß-Glucuronide in Lacrimal Gland Fluid of Rabbits Treated with 13-Cis Retinoic Acid" --- 1990
Folder 34: "The Effect of Retinoic Acid on Thymidine Incorporation and Morphology of Corneal Stromal Fibroblasts" --- 1990
Folder 35: "Dry-Eye Syndromes" - a Handbook --- 1991
Folder 36: "Quantitative Evaluation of the Corneal Epithelial Barrier: Effect of Artificial Tears and Preservatives" --- 1991
Folder 37: "Retinoic Acid Decreases the Number of EGF Receptors in Corneal Epithelium and Chang Conjunctival Cells" --- 1991
Folder 38: "Inhibition of Corneal Epithelial Cell Migration by Cadmium and Mercury" --- 1991
Folder 39: "Bile Salt-Independent Retinyl Ester Hydrolase in the Rat Lacrimal Gland" --- 1991
Folder 40: "Manual of Oculotoxicity Testing of Drugs" --- 1992
Folder 41: "Retinyl Ester Hydrolysis in the Rabbit Lacrimal Gland" --- 1992
Folder 42: "The Lacrimal Gland Synthesizes Retinol-Binding Protein" --- 1992
Folder 43: "Artificial Tear Composition and Promotion of Recovery of the Damaged Corneal Epithelium" --- 1992
Folder 44: "Cellular Retinol-binding Protein and Cellular Retinoic Acid-Binding Protein in the Lacrimal Gland" --- 1993
Folder 45: "The Influence of Retinoic Acid on Growth and Morphology of Rat Exorbital Lacrimal Gland Acinar Cells in Culture" --- 1994
Folder 46: "The Rabbit Lacrimal Gland in Vitamin A Deficiency" --- 1994
Folder 47: "Evaluation of Effects of a Physiologic Artificial Tear of the Corneal Epitthelial Barrier: Electrical Resistance and Carboxyflourescein Permeability" --- 1994
Folder 48: "The Cornea Stroma" --- 1994
Folder 49: "Biological Activity of N-(4-Hydroxyphenyl) Retinamide-O-Glucuronide in Corneal and Conjunctive Cells of Rabbits and Humans" --- 1995
Folder 50: "Nuclear Retonic Acid Receptors in the Lacrimal Gland" --- 1995
Folder 51: "Effects of Preservative Free Artificial Tear Solutions on Corneal Epithelial Structure and Function" --- 1995
Folder 52: "The Lacrimal Gland Expressed Nuclearn Retinoid X Receptors" --- 1996
Folder 53: "Evaluation and Refinement of the Bovine Cornea Opacity and Permeability Test" --- 1997: Report to Amway Corporation
Folder 54: "Opthalmologic Perspectives on Eye Irritation Testing" --- 1998
Folder 55: "Effect of Hydration on Opacity of the Bovine Corneal Opacity and Permeability (BCOP) Assay" --- 1998
Folder 56: "Effect of Hydration on Opacity of the Bovine Corneal Opacity and Permeability (BCOP) Assay" --- 1998
Folder 57: "N-Linked Glycoside and Glucuronide Conjugates of the Retinoid, Acitretin, Are Biologically Active in Cornea and Conjuctiva" --- 1998
Folder 58: "Conjunctival Permeability and Ultrastructure" --- 1998
Folder 59: "Expression of Nuclear Retinoic Acid Receptor and Retinoid X Receptor mRNA in the Cornea and Conjuctiva" --- 1997
Folder 60: "Intermediate Fragment, laminin and Integrin Expression in Lacrimal Gland Acinar Cells: Comparison of an Immortalized Cell Line to Primary Cells, and their response to Retinoic Acid" --- 1999
Folder 61: "The Eicosanoid, 15-(S)-HETE, Stimulates Secretion of Mucin-like Glycoprotein by the Corneal Epithelium" --- 2000
Folder 62: "Corneal Opacity, Hydration and Endothelial Morphology in the Bovine Corean Opacity and Permeability Assay Using Reduced Treatment Times" --- 2000
Folder 63: "Investigating Live and Fixed Epithelial Fibroplast Cells by Atomic Force Microscopy" --- 2001
Folder 64: "A Redesigned Corneal Holder for the Bovine Cornea Opacity and Permeability Assay that Maintains Normal Conreal Morphology" --- 2002
Folder 65: "Down-Regulation of Androgen Receptor Expression and Inhibition of Lacrimal Gland Cell Proliferation by Retinoic Acid" --- 2002
Folder 66: "Topically Applied 15-(S)-Hete Stimulates Mucin Production by Corneal Epithelium" --- 2002
Folder 67: "Identification of Androgen Receptors in Rabbit Lacrimal Gland by Immunohistochemistry" --- 2002
Folder 68: "Artificial Tear Solutions and Protection of the Corneal Epithelium from Desiccation" --- 2002
Folder 69: "Alternative Toxicological Methods" --- 2003
Folder 70: "The Cornea and the Sclera" --- 2003
Folder 71: "Interactions of Testosterone and All-trans Retinoic Acid in Regulation of Androgen Receptor Expression in Rat Lacrimal Gland" --- 2003
Folder 72: "Corneal Permeability in a Redesigned Corneal Holder for the Bovine Cornea Opacity and Permeability Assay" --- 2004
Folder 73: "Pre-Clinical Investigation of the Efficacy of an Artificial Tear Solution Containing Hydroxypropyl-guar as a Gelling Agent" --- 2004
Folder 74: "A Retrospective on Topical Retinoids Occasioned by Observation of Unexpected Interactions of Retinoic Acid with Androgens and Glucocorticoids in Immortalized Lacrimal Acinar Cells" --- 2004
Folder 75: "In Vitro Alternatives to the Use of Animals in Ocular Toxicology Testing" --- 2005
Folder 76: "Gene Expression in Rat Lacrimal Gland Duct Cells Collected Using Laser Capture Microdissection: Evidence for K+ Secretion by Duct Cells" --- 2005
Folder 77: "Corneal Epithelial Testing Strategies for Safety Evaluation of Opthalmic Formulations" --- 2007
Folder 78: "Research in Dry Eye" --- 2007
Folder 79: "Inhibition of UV-B Induced Apoptosis in Corneal Epithelial Cells by Potassium Channel Modulators" --- 2009
Folder 80: "Elevated Extracellular K+ Inhibits Apoptosis of Corneal Epithelial Cells Exposed to UV-B Radiation" --- 2009
Folder 81: "Cytotoxicity Testing of Multipurpose Contact Lens Solutions Using Monolayer and Stratified Cultures of Human Corneal Epithelial Cells" --- 2009
Folder 82: "Effects of Peroxide-Based Contact Lens-Disinfecting Systems of Human Corneal Epithelial Cells in Vitro" --- 2011
Folder 83: "Stratified Corneal Limbal Epithelial Cells are Protected from UVB-Induced Apoptosis by Elevated Extracellular K+" --- 2011
Folder 84: "Potassium Ion Fluxes in Corneal Epithelial Cells Exposed to UVB" --- 2011
Folder 85: "Gene Expression in Human Accessory Lacrimal Glands of Wolfring" --- 2012
Folder 86: "Differential Regulation of GLUT1 Activity in Human Corneal Limbal Epithelial Cells and Fibroblasts" --- 2012
Folder 87: "Enhancement of Vitamin D Metabolites in the Eye Following Vitamin D3 Supplementation and UV-B Irradiation" --- 2012
Folder 88: "Bioavailability of Antioxidants Applied to Stratified Human Corneal Epithelial Cells" --- 2013
Folder 89: "Involvement of the Extrinsic and Intrinsic Pathways in Ultraviolet B-Induced Apoptosis of Corneal Epithelial Cells" --- 2015
Folder 90: "Apoptosis of Corneal Epithelial Cells Caused by Ultraviolet B-Induced Loss of K+ is Inhibited by Ba2+" --- 2016
Folder 91: "The Effect of K+ on Caspase Activity of Corneal Epithelial Cells Exposed to UVB" --- 2016
Folder 92: "Impairment of Retinal Function in Yellow Perch (Perca flavescens) by Diplostomum baeri Metacercariae" --- 2018

Series 3: Reports to Alcon Research, Ltd.

Box 3

Folder 1: "Effect of Mussel Adhesive Protein on Corneal Epithelial Wound Healing" --- 1987: Report submitted to Alcon Laboratories
Folder 2: "All-Trans Retinoyl-Beta-Glucuronide for Treatment of Ocular Surface Disease" --- 1987: Report submitted to Alcon Laboratories
Folder 3: "Physiologic Efficacy of Artificial Tear Solutions --- 1995: Report submitted to Alcon Laboratories
Folder 4: "The Ocumer Polymer in an Artificial Tear Solution" --- 1997: Report submitted to Alcon Laboratories
Folder 5: "Biological Activity of Water-Soluble Acetretin Derivatives" --- 1997: Report submitted to Alcon Laboratories
Folder 6: "Stimulation of Ocular Surface Mucin Secretion by 15(S)-(HETE)" --- 1999: Report submitted to Alcon Laboratories
Folder 7: Reports to Alcon Research, Ltd. on Dry Eye Relief Research --- 2001
Folder 8: "Testing of Artificial Tear Formulations" --- 2002
Folder 9: "Effects of a Tear Formulation Containing Aminomethylpropanol and HP-guar at Varying pH on Cells in Culture and Rabbit Corneal Epithelium" --- 2003: Report submitted to Alcon Research
Folder 10: "Proliferation of Cells Exposed to AMP at Varying pH" --- 2004
Folder 11: Reports to Alcon Research, Ltd. on Dry Eye Research --- 2005
Folder 12: "Evaluation of Concepts for the Relief of Dry Eye Symptoms" --- 2006: Report submitted to Alcon Research, Ltd.
Folder 13: Reports to Alcon Research, Ltd. on Dry Eye Relief Research --- 2007
Folder 14: "Evaluation ORB Ocular Emulsion Formulations" --- 2006: Report submitted to Alcon Research, Ltd.
Folder 15: "Pre-clinical Toxicologic Evaluation of FID 114675A - Revised" --- 2009: Report submitted to Alcon Research, Ltd.
Folder 16: "In Vitro Viability of Corneal Epithelial Cells Exposed to Forumlations Containing Hydroxypropyl Guar Galactomannan (HPGG)" --- 2007
Folder 17: "Effect of Prolonged Exposure to Hydroxypropyl Guar Galactomannan in Combination with Polyquaternium-1 on the Permeability of Rabbit Corneal Epithelium" --- 2007
Folder 18: "Toxicologic Evaluation of Contact Lens Solutions" --- 2008
Folder 19: "Pre-Clinical Toxicologic Evaluation of Bis-amine Exploratory Formulations (14336-33A, B, C, D, E) --- 2009
Folder 20: "Toxicologic Evaluation of Experimental Hydrogen Peroxide Lens Solutions" --- 2009
Folder 21: "Pre-Clinical Toxicologic Evaluation of Bis-amine Compounds (AL-38571, AL-39586, AL-39503, Bis-Tris, Ultra AMP(AMP-95))" --- 2009
Folder 22: "Evaluation of Experimental Contact Lens Solutions Containing H2O2" --- 2009
Folder 23: "March 2010 Deliverable: Cytotoxicity Testing of Contact Lens Care Soluutions Using Lenses Cycled 10 Times" --- 2010
Folder 24: "Investigation of Contact Lens, Storage Case, and Multipurpose Solution Interaction and their Effects on Corneal Epthelial Cells Using a Lens Overlay Model" --- 2010
Folder 25: "Optimization of a Cellular Antioxidant Activity Assay for Use with Human Coreanl Epthelial Cells" --- 2010
Folder 26: "Stratification of FTT Cells in Culture" --- 2010
Folder 27: "Antioxidant Effects of Genistein in HBSS" --- 2011
Folder 28: "Bioavailability and Activity of Various Antioxidants in Systane Ultra or Systane Balance" --- 2011
Folder 29: "Toxicologic Evaluation of Protective Effect of Dry Eye Formulations Containing Hyaluronic Acid on Stratified Corneal Epithelial Cells" --- 2011
Folder 30: "TNF-R1 and FADD mediate UVB-Induced activation of K+ Channels in corneal epithelial cells" --- 2016
Folder 31: "Prevalence of Refractive Error and Need for Corrective Lenses in Medically Underserved Residents of Tijuana, Mexico" --- 2019
Folder 32: "Patch-clamp Recording of K+ Current from Lacrimal Gland Duct Cells"
Folder 33: Sjogren's Quarterly, "Do No Harm: Why Should You Avoid Benzalkonium Chloride-Containing Artificial Tears" --- 2020
Folder 34: The CRISPR Journal, "Low-Density Lipoprotein Receptor-Related Protein 5-Deficient Rats Have Reduced Bone Mass and Abnornal Development of Retinal Vasculature" --- 2020
Folder 35: Experimental Eye Research, "Structure and function of the retina of low-density lipoprotein receptor-related protein 5 (Lrp5)-deficient rats" --- 2022

Browse by Series:

[Series 1: General Files],
[Series 2: Published Articles],
[Series 3: Reports to Alcon Research, Ltd.],
[All]