.
By Laurie Haan
Collection Overview
Abstract
The John L. Ubels Papers contain papers from Ubels’s career as a professor and scientific consultant. This collection consists of 1.5 linear feet of reports and published studies written between 1976 and 2008. Many of the reports were written for Alcon Laboratories, Ltd.
Scope and Contents of the Materials
The John L. Ubels Papers contain papers from Ubels’s career as a professor and scientific consultant. This collection consists of 1.5 linear feet of reports and published studies written between 1976 and 2008. Many of the reports were written for Alcon Laboratories, Ltd. Many papers were written on the subject of dry eyes and artificial tears.
Collection Historical Note
John L. Ubels was born in Modesto, California on June 9, 1952. He earned a Bachelor of Science degree from Calvin College, a Master of Science degree from the University of Michigan, and a PhD in animal physiology from Michigan State University. He later taught biology at Calvin College from 1995 to 2016.
Dr. Ubels taught human physiology and cell physiology during his time at Calvin University. He led an interim sailing course in Florida and an eye care service-learning interim course in Tijuana, Mexico. During his years at Calvin, he mentored 56 students in his research lab. He did extensive research for Alcon Research, Ltd. on ophthalmology, particularly dry eyes treatments. He did extensive testing for the development of Systane and Artificial Tears. Over the past 44 years, he has published 104 papers and chapters on every part of the eye of fish, amphibians and mammals, including humans. During his retirement, he teaches part time at the Michigan State University College of Human Medicine and is a guest scientist at the Van Andel Research Institute.
Biographical Note
Dr. Ubels taught human physiology and cell physiology during his time at Calvin University. He led an interim sailing course in Florida and an eye care service learning interim course in Tijuana, Mexico. During his years at Calvin, he mentored 56 students in his research lab. He did extensive research for Alcon Research Ltd. on opthmology, particularly dry eyes treatments. He did extensive testing for the development of Systane and Artifical Tears. Over the past 44 years, he has published 104 papers and chapters on every part of the eye of fish, amphibians and mammals, including humans. During his retirement, he teaches part time at the Michigan State University College of Human Medicine and is a guest scientist at the Van Andel Research Institute
Subject/Index Terms
Administrative Information
Repository:
Heritage Hall, Hekman Library
Access Restrictions:
<span style="color: rgb(16, 55, 93); font-family: Verdana, Arial, sans-serif; font-size: 12.96px;">Collection held in Heritage Hall; materials are not available for circulation</span>
Acquisition Source:
Gift of John L. Ubels
Acquisition Method:
Donation
Box and Folder Listing
Browse by Series:
[
Series 1: General Files],
[Series 2: Published Articles],
[
Series 3: Reports to Alcon Research, Ltd.],
[
All]
- Series 2: Published Articles
- Box 2
- Folder 1: "Ocular Oxygen Toxicity: The Effect of Hyperbaric Oxygen on the In Vitro Electroretinogram" --- 1976 September 7
- Folder 2: "Electrophysiological and Metabolic Responses of the Isolated Teleost Retina To Changes in PO2 and Temperature" --- 1978 March 29
- Folder 3: "Retinomotor Activity and the C-wave of the Hypoxic Trout Retina" --- 1979 July
- Folder 4: "Ocular Oxygen Toxicity: The Effect of Hyperbaric Oxygen on Retinal Na+ - K+ ATPase --- 1980 February 27
- Folder 5: "Retinoid Permeability and Uptake of Corneas of Normal and Vitamin A Deficient Rabbits" --- 1982 November
- Reprinted from the Archives of Opthamology
- Folder 6: "Measurement of Corneal Epithelial Healing Rates and Corneal Thickness for Evaluation of Ocular Toxicity of Chemical Substances" --- 1982
- Folder 7: "A Comparison of Healing of Corneal Epithelial Wounds Stained with Fluorescein or Richardson's Stain" --- 1982 July
- Folder 8: "Healing of Experimental Corneal Wounds Treated with Topically Applied Retinoids" --- 1983 March
- Folder 9: "Healing of Corneal Epithelial Wounds in Marine and Freshwater Fish" --- 1983
- Folder 10: "Vitamin A is Present as a Retinol in the Tears of Humans and Rabbits" --- 1984
- Folder 11: "Chorodial Rete Mirabile Function and Resistance to Retinal Oxygen Toxicity in Fish" --- 1984
- Folder 12: "Ocular Toxicity of Diethyltoluamide (DEET)" --- 1984
- Folder 13: "Corneal Epithelial Wound Healing in Normal and Diabetic Rabbits Treated with Tretinoin" --- 1985 January
- Folder 14: "The Efficacy of Retinoic Acid Ointment for Treatment of Xerophtalmia and Corneal Epithelial Wounds" --- 1985
- Folder 15: "In Vivo Metabolism of Topically Applied Retional and All-Trans Retinoic Acid by the Rabbit Cornea" --- 1985
- Folder 16: "Retinol Secretion by the Lacrimal Gland" --- 1986
- Folder 17: "Corneal Endothelial Healing Rate and the Effect of Topical Retinoic Acid" --- 1986
- Folder 18: "Treatment of Corneal Xerophthalmia in Rabbits with Micromolar Doses of Topical Retinoic Acid" --- 1987
- Folder 19: Report to Alcon Labs: "Drug Uptake and Washout" - IOGEL Lens --- 1987 November 25
- Folder 20: Isotretinoin in Lacrimal Gland Fluid and Tears --- 1987
- Folder 21: "Effects of Corneal Epithelial Abrasion on Corneal Transparency Aqueous Humor Composition and Lens of Fish" --- 1987
- Folder 22: "Role of the Rabbit Nictitating Membrane in Ocular Irritancy Testing" --- 1987
- Folder 23: "Vitamin A is Stored as Fatty Acyl Esters of Retinol in the Lacrimal Gland" --- 1988
- Folder 24: "Corneal Endothelial Morphology in the Rat" --- 1988
- Folder 25: "Tear Secretion and Lacrimal Gland Function of Rabbits Treated wiht Isotretinoin" --- 1988
- Folder 26: "Drug Uptake and Release by Hydrogel Intraocular Lens and the Human Cyrstalline Lens" --- 1989
- Folder 27: "Esterification of Retinol in Lacrimal Glad" --- 1989
- Folder 28: "Electrolyte Composition of Lacrimal Gland F;uid and Tears of Normal and Vitamin A-Deficient Rabbits" --- 1989
- Folder 29: "The Relationship Between Secretion of Retinol and Protein by the Lacrimal Gland" --- 1989
- Folder 30: Report ot CIBA Vision Copropration, Atlanta, Georgia: "Effect of an Opthalmic Preservative on Corneal Epithelial Wound Healing" --- 1989
- Folder 31: Report to S. C. Johnson"Evaluation of Ocular Irritancy of Hair Care Products" --- 1990
- Folder 32: "Evaluation of Ocular Irritancy of Hair Care Products" --- 1990
- Folder 33: "13-Cis Retinoyl-ß-Glucuronide in Lacrimal Gland Fluid of Rabbits Treated with 13-Cis Retinoic Acid" --- 1990
- Folder 34: "The Effect of Retinoic Acid on Thymidine Incorporation and Morphology of Corneal Stromal Fibroblasts" --- 1990
- Folder 35: "Dry-Eye Syndromes" - a Handbook --- 1991
- Folder 36: "Quantitative Evaluation of the Corneal Epithelial Barrier: Effect of Artificial Tears and Preservatives" --- 1991
- Folder 37: "Retinoic Acid Decreases the Number of EGF Receptors in Corneal Epithelium and Chang Conjunctival Cells" --- 1991
- Folder 38: "Inhibition of Corneal Epithelial Cell Migration by Cadmium and Mercury" --- 1991
- Folder 39: "Bile Salt-Independent Retinyl Ester Hydrolase in the Rat Lacrimal Gland" --- 1991
- Folder 40: "Manual of Oculotoxicity Testing of Drugs" --- 1992
- Folder 41: "Retinyl Ester Hydrolysis in the Rabbit Lacrimal Gland" --- 1992
- Folder 42: "The Lacrimal Gland Synthesizes Retinol-Binding Protein" --- 1992
- Folder 43: "Artificial Tear Composition and Promotion of Recovery of the Damaged Corneal Epithelium" --- 1992
- Folder 44: "Cellular Retinol-binding Protein and Cellular Retinoic Acid-Binding Protein in the Lacrimal Gland" --- 1993
- Folder 45: "The Influence of Retinoic Acid on Growth and Morphology of Rat Exorbital Lacrimal Gland Acinar Cells in Culture" --- 1994
- Folder 46: "The Rabbit Lacrimal Gland in Vitamin A Deficiency" --- 1994
- Folder 47: "Evaluation of Effects of a Physiologic Artificial Tear of the Corneal Epitthelial Barrier: Electrical Resistance and Carboxyflourescein Permeability" --- 1994
- Folder 48: "The Cornea Stroma" --- 1994
- Folder 49: "Biological Activity of N-(4-Hydroxyphenyl) Retinamide-O-Glucuronide in Corneal and Conjunctive Cells of Rabbits and Humans" --- 1995
- Folder 50: "Nuclear Retonic Acid Receptors in the Lacrimal Gland" --- 1995
- Folder 51: "Effects of Preservative Free Artificial Tear Solutions on Corneal Epithelial Structure and Function" --- 1995
- Folder 52: "The Lacrimal Gland Expressed Nuclearn Retinoid X Receptors" --- 1996
- Folder 53: "Evaluation and Refinement of the Bovine Cornea Opacity and Permeability Test" --- 1997
- Report to Amway Corporation
- Folder 54: "Opthalmologic Perspectives on Eye Irritation Testing" --- 1998
- Folder 55: "Effect of Hydration on Opacity of the Bovine Corneal Opacity and Permeability (BCOP) Assay" --- 1998
- Folder 56: "Effect of Hydration on Opacity of the Bovine Corneal Opacity and Permeability (BCOP) Assay" --- 1998
- Folder 57: "N-Linked Glycoside and Glucuronide Conjugates of the Retinoid, Acitretin, Are Biologically Active in Cornea and Conjuctiva" --- 1998
- Folder 58: "Conjunctival Permeability and Ultrastructure" --- 1998
- Folder 59: "Expression of Nuclear Retinoic Acid Receptor and Retinoid X Receptor mRNA in the Cornea and Conjuctiva" --- 1997
- Folder 60: "Intermediate Fragment, laminin and Integrin Expression in Lacrimal Gland Acinar Cells: Comparison of an Immortalized Cell Line to Primary Cells, and their response to Retinoic Acid" --- 1999
- Folder 61: "The Eicosanoid, 15-(S)-HETE, Stimulates Secretion of Mucin-like Glycoprotein by the Corneal Epithelium" --- 2000
- Folder 62: "Corneal Opacity, Hydration and Endothelial Morphology in the Bovine Corean Opacity and Permeability Assay Using Reduced Treatment Times" --- 2000
- Folder 63: "Investigating Live and Fixed Epithelial Fibroplast Cells by Atomic Force Microscopy" --- 2001
- Folder 64: "A Redesigned Corneal Holder for the Bovine Cornea Opacity and Permeability Assay that Maintains Normal Conreal Morphology" --- 2002
- Folder 65: "Down-Regulation of Androgen Receptor Expression and Inhibition of Lacrimal Gland Cell Proliferation by Retinoic Acid" --- 2002
- Folder 66: "Topically Applied 15-(S)-Hete Stimulates Mucin Production by Corneal Epithelium" --- 2002
- Folder 67: "Identification of Androgen Receptors in Rabbit Lacrimal Gland by Immunohistochemistry" --- 2002
- Folder 68: "Artificial Tear Solutions and Protection of the Corneal Epithelium from Desiccation" --- 2002
- Folder 69: "Alternative Toxicological Methods" --- 2003
- Folder 70: "The Cornea and the Sclera" --- 2003
- Folder 71: "Interactions of Testosterone and All-trans Retinoic Acid in Regulation of Androgen Receptor Expression in Rat Lacrimal Gland" --- 2003
- Folder 72: "Corneal Permeability in a Redesigned Corneal Holder for the Bovine Cornea Opacity and Permeability Assay" --- 2004
- Folder 73: "Pre-Clinical Investigation of the Efficacy of an Artificial Tear Solution Containing Hydroxypropyl-guar as a Gelling Agent" --- 2004
- Folder 74: "A Retrospective on Topical Retinoids Occasioned by Observation of Unexpected Interactions of Retinoic Acid with Androgens and Glucocorticoids in Immortalized Lacrimal Acinar Cells" --- 2004
- Folder 75: "In Vitro Alternatives to the Use of Animals in Ocular Toxicology Testing" --- 2005
- Folder 76: "Gene Expression in Rat Lacrimal Gland Duct Cells Collected Using Laser Capture Microdissection: Evidence for K+ Secretion by Duct Cells" --- 2005
- Folder 77: "Corneal Epithelial Testing Strategies for Safety Evaluation of Opthalmic Formulations" --- 2007
- Folder 78: "Research in Dry Eye" --- 2007
- Folder 79: "Inhibition of UV-B Induced Apoptosis in Corneal Epithelial Cells by Potassium Channel Modulators" --- 2009
- Folder 80: "Elevated Extracellular K+ Inhibits Apoptosis of Corneal Epithelial Cells Exposed to UV-B Radiation" --- 2009
- Folder 81: "Cytotoxicity Testing of Multipurpose Contact Lens Solutions Using Monolayer and Stratified Cultures of Human Corneal Epithelial Cells" --- 2009
- Folder 82: "Effects of Peroxide-Based Contact Lens-Disinfecting Systems of Human Corneal Epithelial Cells in Vitro" --- 2011
- Folder 83: "Stratified Corneal Limbal Epithelial Cells are Protected from UVB-Induced Apoptosis by Elevated Extracellular K+" --- 2011
- Folder 84: "Potassium Ion Fluxes in Corneal Epithelial Cells Exposed to UVB" --- 2011
- Folder 85: "Gene Expression in Human Accessory Lacrimal Glands of Wolfring" --- 2012
- Folder 86: "Differential Regulation of GLUT1 Activity in Human Corneal Limbal Epithelial Cells and Fibroblasts" --- 2012
- Folder 87: "Enhancement of Vitamin D Metabolites in the Eye Following Vitamin D3 Supplementation and UV-B Irradiation" --- 2012
- Folder 88: "Bioavailability of Antioxidants Applied to Stratified Human Corneal Epithelial Cells" --- 2013
- Folder 89: "Involvement of the Extrinsic and Intrinsic Pathways in Ultraviolet B-Induced Apoptosis of Corneal Epithelial Cells" --- 2015
- Folder 90: "Apoptosis of Corneal Epithelial Cells Caused by Ultraviolet B-Induced Loss of K+ is Inhibited by Ba2+" --- 2016
- Folder 91: "The Effect of K+ on Caspase Activity of Corneal Epithelial Cells Exposed to UVB" --- 2016
- Folder 92: "Impairment of Retinal Function in Yellow Perch (Perca flavescens) by Diplostomum baeri Metacercariae" --- 2018
Browse by Series:
[
Series 1: General Files],
[Series 2: Published Articles],
[
Series 3: Reports to Alcon Research, Ltd.],
[
All]
